The multiple emulsion formulations containing Atorvastatin were optimized for oil phase; different formulation parameters like type and concentration of primary emulsifier & secondary emulsifier, phase volume ratio and effect of additives; and different process variables like speed and time of stirring for primary and secondary emulsification; on the basis of different evaluation parameters like entrapment efficiency, stability, globule size, viscosity and in vitro release profile. Atorvastatin is commonly used for the treatment of hyperlipidemia or hypercholesterolemia but it suffers from the problem of low bioavailability through oral route. Based on the hypothesis that improved release profile leads to enhanced bioavailability, the present study was aimed to optimize various processing parameters to obtain stable multiple emulsions with high encapsulation efficiency and improved release profile.
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